| Act 1 | Safe Level Target | Must Complete Before Continuing |
| Twilight Strand | 4 | |
| Coast | 8 | |
| Tidal Island | 9 | Quest |
| Fetid Pool | 11 | Quest |
| Mud Flats | 11 | Quest |
| Flooded Depths | 13 | Quest |
| Submerged Passage | 13 | |
| Ledge | 13 | |
| Climb | 14 | |
| Prison | 18 | Quest, Trial of Ascendancy |
| Prisoner's Gate | 19 | |
| Ship Graveyard Cave | 20 | Quest |
| Ship Graveyard | 20 | Quest |
| Merveil's Caverns | 21 | Quest |
| Act 2 | Safe Level Target | Must Complete Before Continuing |
| Southern Forest | 22 | |
| Den | 22 | Quest |
| Riverways | 25 | |
| Western Forest | 26 | Quest |
| Wetlands | 28 | Quest |
| Crossroads | 28 | |
| Broken Bridge | 28 | Quest |
| Chamber of Sins | 28 | Quest, Trial of Ascendancy |
| Fellshrine Ruins | 28 | |
| Crypt | 28 | Quest, Trial of Ascendancy |
| Weaver's Chambers | 28 | Quest |
| Vaal Ruins | 29 | Quest |
| Northern Forest | 30 | |
| Caverns | 33 | Quest |
| Act 3 | Safe Level Target | Must Complete Before Continuing |
| City of Sarn | 33 | Quest |
| Slums | 34 | |
| Crematorium | 35 | Quest, Trial of Ascendancy |
| Sewers | 36 | Quest |
| Marketplace | 36 | |
| Catacombs | 37 | Trial of Ascendancy |
| Battlefront | 37 | Quest |
| Docks | 40 | Quest |
| Solaris Temple Level 1 | 40 | |
| Solaris Temple Level 2 | 40 | Quest |
| Ebony Barracks | 40 | Quest |
| Lunaris Temple | 41 | Quest |
| Imperial Gardens | 41 | Quest, Trial of Ascendancy |
| Library | 41 | Quest |
| Lord's Labyrinth | 41 | Trial of Ascendancy |
| Sceptre of God | 43 | Quest |
| Act 4 | Safe Level Target | Must Complete Before Continuing |
| Aqueduct | 43 | |
| Dried Lake | 45 | Quest |
| Mines | 45 | Quest |
| Crystal Veins | 46 | |
| Kaom's Dream | 47 | |
| Kaom's Stronghold | 50 | Quest |
| Daresso's Dream | 50 | |
| Grand Arena | 50 | Quest |
| Belly of the Beast | 50 | Quest |
| Harvest | 51 | Quest |
| Ascent | 51 | |
| Act 5 | Safe Level Target | Must Complete Before Continuing |
| Slave Pens | 52 | |
| Control Blocks | 52 | Quest |
| Oriath Square | 54 | |
| Templar Courts | 54 | |
| Chamber of Innocence | 55 | Quest |
| Torched Courts | 55 | |
| Ruined Square | 55 | Quest |
| Reliquery | 55 | Quest |
| Ossuary | 55 | Quest |
| Cathedral Rooftop | 57 | Quest |
| Act 6 | Safe Level Target | Must Complete Before Continuing |
| Twilight Strand | 57 | Quest |
| Coast | 57 | |
| Tidal Island | 57 | Quest |
| Mud Flats | 58 | Quest |
| Karui Fortress | 58 | Quest |
| Ridge | 58 | |
| Prison | 59 | Quest, Trial of Ascendancy |
| Prisoner's Gate | 59 | Quest |
| Western Forest | 60 | |
| Riverways | 60 | |
| Wetlands | 60 | Quest |
| Southern Forest | 61 | |
| Cavern of Anger | 61 | |
| Beacon | 62 | Quest |
| Brine King's Reef | 63 | Quest |
| Act 7 | Safe Level Target | Must Complete Before Continuing |
| Broken Bridge | 63 | Quest |
| Crossroads | 64 | |
| Fellshrine Ruins | 64 | |
| Crypt | 64 | Quest, Trial of Ascendancy |
| Chamber of Sins | 65 | Quest, Trial of Ascendancy |
| Maligaro's Sanctum | 65 | Quest |
| Den | 66 | |
| Ashen Fields | 66 | Quest |
| Northern Forest | 66 | Quest |
| Dread Thicket | 66 | Quest |
| Causeway | 67 | Quest |
| Vaal City | 67 | |
| Temple of Decay | 67 | Quest |
| Act 8 | Safe Level Target | Must Complete Before Continuing |
| Sarn Ramparts | 68 | |
| Toxic Conduits | 69 | Quest |
| Grand Promenade | 69 | |
| Bath House | 70 | Quest, Trial of Ascendancy |
| High Gardens | 71 | Quest |
| Lunaris Concourse | 71 | |
| Lunaris Temple | 72 | Quest |
| Quay | 72 | Quest |
| Grain Gate | 72 | Quest |
| Imperial Fields | 72 | |
| Solaris Temple | 72 | Quest |
| Solaris Concourse | 72 | |
| Lord's Labyrinth | 72 | Trial of Ascendancy |
| Harbour Bridge | 73 | |
| Act 9 | Safe Level Target | Must Complete Before Continuing |
| Blood Aqueduct | 74 | |
| Descent | 74 | |
| Vastiri Desert | 74 | Quest |
| Oasis | 74 | Quest |
| Foothills | 75 | Quest |
| Boiling Lake | 75 | Quest |
| Tunnel | 75 | Trial of Ascendancy |
| Quarry | 76 | Quest |
| Refinery | 76 | Quest |
| Belly of the Beast | 76 | |
| Rotting Core | 77 | Quest |
| Act 10 | Safe Level Target | Must Complete Before Continuing |
| Cathedral Rooftop | 77 | Quest |
| Ravaged Square | 77 | |
| Torched Courts | 78 | |
| Desecrated Chambers | 78 | Quest |
| Control Blocks | 79 | Quest |
| Reliquary | 80 | Quest |
| Ossuary | 80 | Quest, Trial of Ascendancy |
| Lord's Labyrinth | 80 | Trial of Ascendancy |
| Canals | 80 | Quest |
| Feeding Trough | 80 | Quest |